Pioneering Advanced Vascular Access Solutions for Hemodialysis
An unmet need exists for a therapy that promotes successful AVF maturation without the need for multiple additional interventions, while maintaining the functionality and flexibility of the vascular wall.
AVF is the preferred vascular access for hemodialysis but often fails to mature into a viable, high-flow conduit.
interventions per year are required to mature or repair AVFs
4-6
2-3
On average
of AVFs require intervention to facilitate maturation
3
50%
of AVFs fail to
mature
1, 2
60%
Up to
1 Al-Jaishi AA, Oliver MJ, Thomas SM, Lok CE, Zhang JC, Garg AX, Kosa SD, Quinn RR, Moist LM. Patency rates of the arteriovenous fistula for hemodialysis: a systematic review and meta-analysis. Am J Kidney Dis. 2014 Mar;63(3):464-78. doi: 10.1053/j.ajkd.2013.08.023. Epub 2013 Oct 30. PMID: 24183112.
2 Dember LM, Beck GJ, Allon M, Delmez JA, Dixon BS, Greenberg A, Himmelfarb J, Vazquez MA, Gassman JJ, Greene T, Radeva MK, Braden GL, Ikizler TA, Rocco MV, Davidson IJ, Kaufman JS, Meyers CM, Kusek JW, Feldman HI; Dialysis Access Consortium Study Group. Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial. JAMA. 2008 May 14;299(18):2164-71. doi: 10.1001/jama.299.18.2164. PMID: 18477783; PMCID: PMC4943222.
3 Lee TQJ, Zhang Y, Thamer M, Allon M: Long-term outcomes of arteriovenous fistulas with unassisted versus assisted maturation: A retrospective, National Hemodialysis Cohort Study. J Am Soc Nephrol 30: 2209–2218, 2019
4 Falk A. Maintenance and salvage of arteriovenous fistulas. J Vasc Interv Radiol. 2006 May;17(5):807-13. doi: 10.1097/01.RVI.0000217928.43396.35. PMID: 16687746.
5 Kimball TA, Barz K, Dimond KR, Edwards JM, Nehler MR. Efficiency of the kidney disease outcomes quality initiative guidelines for preemptive vascular access in an academic setting. J Vasc Surg. 2011 Sep;54(3):760-5; discussion 765-6. doi: 10.1016/j.jvs.2011.03.006. Epub 2011 Jun 23. PMID: 21703804.
6 Yang S, Lok C, Arnold R, Rajan D, Glickman M. Comparison of post-creation procedures and costs between surgical and an endovascular approach to arteriovenous fistula creation. J Vasc Access. 2017 Mar 28;18(Suppl. 2):8-14. doi: 10.5301/jva.5000723. Epub 2017 Mar 25. PMID: 28362044.
Alucent Natural Vascular Scaffolding
INTRODUCING
®
A light-activated coated balloon technology designed to improve the success rate of arteriovenous fistula (AVF) maturation and enable more reliable initiation of hemodialysis.